Marc Wallice got into the porn industry in 1982 at the age of 22. He was working as a grocery store bagger when he answered an ad for the World Modeling Agency. He started out with non-speaking roles, but worked his way up to become a very active actor, doing more than 1,300 heterosexual porn movies.

He appeared in at least one gay film, A Matter of Size (Huge Video, 1983, Director Matt Sterling), under the name Don Webber. In this movie, he performed oral and anal sex in both the top and bottom roles with Scott Avery and Brian Michaels. He has also been involved in a series of photo shoots that involve him, Debi Diamond and assorted males in a series of threesomes in which he and Diamond both have sexual contact with the males and also Diamond engages in Pegging on both Wallice and the other males who participate.

Just as he was starting to get behind the camera to direct his own movies, it was announced by an industry testing lab on April 30, 1998 that he was HIV-positive. His career suddenly ended with rumors and speculation that he had infected several actresses, including Brooke Ashley, Tricia Devereaux, Caroline, Nina Cherry, Jordan McKnight, Barbara Doll, and Kimberly Jade. Some believe that he forged his HIV results, a rumor that he denies.

He soon left the hardcore scene completely, neither acting nor directing, as many in the industry still had bitter feelings toward him.

Marc later returned to work in the industry. In the past several years, he has worked on editing videos of adult films.